At Fertility Associates, we’re committed to bringing world leading fertility technology to New Zealand to ensure our patients have the best chance of having a healthy baby.
- Pre-Implantation Genetic Screening 'PGS'
- Time Lapse Morphometry Imaging 'TiMI'
- Genetic Carrier Screening
- Endometrial Receptivity Assay - 'ERA'
- AOA - Artificial Oocyte Activation
- hCG infusion before Embryo transfer
Pre-Implantation Genetic Screening (PGS)
PGS checks the number of chromosomes in each blastocyst and can be useful for:
- women 36 and older with good ovarian reserve,
- people who have had recurrent miscarriage,
- people not pregnant despite the transfer of several embryos – PGS may uncover a higher than expected chromosome abnormality rate
- patients who are willing to go through more than one egg retrieval cycle to obtain a normal embryo
Time Lapse Morphometry Imaging (TIMI)
Photographs embryos every 10 minutes to capture developmental milestones in an embryo’s life that
are missed when embryos are only inspected once a day.
TiMI can be useful for:
- people who expect to have several good quality embryos
- people who have had low quality embryos previously may experience better embryo development or learn why embryo development is poor.
High magnification ICSI (IMSI)
When there is significant male infertility, the embryologist injects a sperm into each egg using a technique called ICSI. IMSI is a variation of ICSI using high magnification. ICSI can be useful for
- Men with poor sperm morphology. Poor morphology makes sperm more susceptible to oxidation damage
- Men with a higher level of DNA fragmentation in their sperm. DNA
fragmentation is a sign of oxidation damage
- People with few embryos developing to the blastocyst stage
- People not pregnant despite the transfer of several reasonable quality embryos.
Pre-implantation Genetic Diagnosis ‘PGD’
PGD can be used by people who have a chance of passing serious genetic disorders on to their children, such as:
- Cystic Fibrosis, Huntington’s, Beta-thalessemia, Fragile X and Spinal Muscular Atrophy. These are caused by a change in single gene.
- People who have a high chance of pregnancy loss or a lower chance of pregnancy because of translocations between chromosomes.
Useful to know:
Ethics Committee approval is required to carry out PGD for any other reason (such as ‘saviour siblings’). PGD cannot be used for gender selection in New Zealand.
Genetic Carrier Screening
Genetic carrier screening gives individuals and couple’s information about their risk of having a child with a genetic condition.
We now offer the option to do genetic testing through Invitae, either for your own information or to check compatibility with your partner or potential donor.
Genetic screening identifies whether you are a carrier of a range of inherited conditions. Most people are carriers of one or more genetic conditions, even though no one in their family has the condition. Being a carrier is important if the person using the sperm is also a carrier of the same condition.
Invitae’s carrier screening includes:
- Severe and prevalent disorders seen across all ethnicities
- Enhanced SMA testing to help identify silent carriers
- Comprehensive Fragile X analysis, including AGG interruptions
- Full gene sequencing with deletion and duplication analysis leading to a 99% detection rate for most genes
- Actionable results; no reporting of variants of unknown significance
For most women the time of endometrial receptivity for an embryo to implant is accurately predicted by the number of days after ovulation, but for some women the ‘window for implantation’ occurs later or earlier. The Endometrial Receptivity Assay or ERA is a method whereby the endometrium may be checked to determine whether the date of embryo transfer may need to be adjusted to match the woman’s own window for implantation.
How it works:
- The woman goes through a mock frozen embryo transfer cycle and on the day of embryo transfer instead of replacing an embryo a Pipelle biopsy is done.
- This is where a small sample of the lining or endometrium is taken and then couriered to the ERA lab. (For NZ the nearest lab is Japan).
- The ERA lab then checks the expression of 238 genes in the biopsy sample and sends a report indicating a receptive endometrium or a pre-receptive or post receptive endometrium.
- The timing of the embryo transfer is then adjusted accordingly.
Who should do this test?
The current recommendations are that the ERA may be useful in women with recurrent implantation failure. There is debate about what the definition of implantation failure is, I think reasonable to consider ERA if a pregnancy has not resulted after the transfer of 2 to 3 good quality embryos into a normal uterus, in which the expectation of greater than 80% would have become pregnant.
Please talk to your Fertility Associates medical team if you would like to know more.
Pre Natal Testing
It is possible to detect/screen for fetal abnormalities using non-invasive prenatal testing 'NIPT', Chorionic Villus Sampling 'CVS' or Amniocentesis.
- NIPT (non-invasive prenatal testing) - Available in our Auckland clinic only - is a blood test performed any time from 10 weeks of pregnancy. The results are available within 5-10 days. NIPT uses cell-free fetal DNA (cfDNA) found in maternal blood to identify the most common chromosome conditions seen in newborns, Trisomy 21 (Down Syndrome), Trisomy 18, Trisomy 13 and Sex chromosome abnormalities including Turner syndrome, Klinefelter syndrome , Triple X and XYY syndrome.
- CVS Chorionic Villus Sampling or Amniocentesis can also be used to confirm a diagnosis in those with a higher risk from the screening result. Screening is free for CVS or Amniocentesis for those at higher risk.
Please ask your Obstetrician, Genetic Counsellor or Lead Maternity Carer for more information
hcG infusion before Embryo transfer
Several studies have shown that a small amount of the hormone human Chorionic Gonadotrophin (hCG) infused into the uterus shortly before embryo transfer may increase the chance of an embryo implanting. This is an ‘Add-on’ treatment that Fertility Associates currently offers.
The chance of an embryo implanting depends on the quality of the embryo and the receptivity of the uterus. Little is known about how to influence the receptivity of the uterus, but there have been several studies looking at the infusion of a small amount of the hormone hCG before embryo transfer.
A recent meta-analysis looked at the results from 15 randomised control studies that included over 2500 patients. The conclusion was that on average infusion of hCG increased the chance of a live birth after embryo transfer. It also appeared to lower the chance of miscarriage. hCG infusion seemed to be more effective for the transfer of fresh embryos than frozen embryos. An infusion within 15 minutes of embryo transfer seemed to be more effective than an infusion done earlier, and a dose of around 500iu seemed to be better than higher doses.
Overall, the evidence for a potentially beneficial effect of hCG infusion is quite high, so this is one of the Add-ons which we classify as of ‘possible benefit’.